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PAβN dihydrochloride

CAS No. 100929-99-5

PAβN dihydrochloride ( MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride )

Catalog No. M22016 CAS No. 100929-99-5

PAβN dihydrochloride is an inhibitor of efflux pump. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold.?

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PAβN dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PAβN dihydrochloride is an inhibitor of efflux pump. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold.?
  • Description
    PAβN dihydrochloride is an inhibitor of efflux pump. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold.?Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates.?In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates.
  • Synonyms
    MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial; efflux pump
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    100929-99-5
  • Formula Weight
    519.47
  • Molecular Formula
    C25H32Cl2N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:95mg/ml (182.88 Mm);H2O:14.29 mg/mL (27.51 mM; Need ultrasonic)
  • SMILES
    Cl.Cl.N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1=CC2=CC=CC=C2C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16.
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